|
KMID : 1007520080170061357
|
|
Food Science and Biotechnology
2008 Volume.17 No. 6 p.1357 ~ p.1360
|
|
|
Antibacterial Activity of Panduratin A and Isopanduratin A Isolated from Kaempferia pandurata Roxb. against Acne-causing Microorganisms
|
|
Song Min-Soo
Lee Chan-Woo
Kim Han-Sung
Gwon Song-Hui
Shim Jae-Seok
Hwang Jae-Kwan
|
|
|
Abstract
|
|
|
|
Propionibacterium acnes is the predominant organism in sebaceous regions of the skinand is thought to play animportant role in the pathogenesis of inflamed lesions. Antibacterial compounds against P. acnes were isolated from theethanol extract of Kaempferia pandurata Roxb. and identified as panduratin A and isopanduratin A. Minimum inhibitoryconcentration (MIC) and minimum bactericidal concentration (MBC) of panduratin A for P. acnes were 2 and 4μg/mL,respectively, while those of isopanduratin A were 4 and 8μg/mL, respectively. The time-dependent killing effect showed thatpanduratin A and isopanduratin A completely inhibited the growth of P. acnes at 4 and 8μg/mL in 48hr, respectively.Panduratin A and isopanduratin A demonstrated high antibacterial activities not only against P. acnes but also other skinmicroorganisms. The results suggest that panduratin A and isopanduratin A could be employed as natural antibacterial agentsto inhibit the growth of acne and skin disease causing microorganisms.
|
|
|
KEYWORD
|
|
|
antibacterial, panduratin A, isopanduratin A, Kaempferia pandurata Roxb., Propionibacterium acnes, skin diseasemicroorganism
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|